As global water scarcity deepens, Direct Potable Reuse (DPR) is emerging as a critical strategy for urban water security and climate resilience. This IDRA fact sheet provides a comprehensive global status update, covering the technological, regulatory, and social landscape across every major region, from pioneering systems in Namibia, Texas, and Singapore to accelerating plans in Europe, the Middle East, and Asia. It sets out IDRA’s position on DPR, examines the economic, social, and environmental case for adoption, and charts the strategic outlook toward 2050.